Síntesis y caracterización de derivados O-acilados y O-alquilados de lawsona
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https://doi.org/10.65093/aci.v16.n2.2025.27Palabras clave:
1,4 naftoquinonas, lawsona, derivados O-acilados, síntesis orgánicaResumen
Las naftoquinonas son compuestos orgánicos con amplia relevancia biológica y aplicaciones en química médica y agrícola. En este trabajo se describe la síntesis de los derivados conocidos de lawsona (1), 2‑acetoxi (2) y 2‑metoxi (3) de, junto con cuatro nuevos compuestos O‑acilados (4–7) obtenidos mediante reacciones de O‑alquilación y O‑acilación. Los productos fueron caracterizados por FT‑IR, RMN 1D y 2D, y espectrometría de masas de alta resolución (EMAR), confirmando sus estructuras. Los rendimientos oscilaron entre 49,3 % y 89,2 %, observándose variaciones atribuibles a la naturaleza del grupo acilo. Estos resultados establecen la base para estudios posteriores orientados a evaluar la actividad antifúngica frente a fitopatógenos de importancia agrícola.
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